Certain cannabis compounds are capable of preventing the virus responsible for COVID-19 from entering human cells. More Information on where to buy CBD with CBGA and CBDA
Researchers from Oregon State University discovered a pair of cannabinoid acid pairs that bind to the spike protein of the SARS virus. This blocks a crucial step in the virus’ infective process.
The cannabis compounds can be taken orally, are abundant in hemp, and block the alpha and beta versions from infecting human cells. However, the team points out that those are only the two variants they have studied.
According to the team, this means that the compounds could be effective in blocking other coronavirus viruses.
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Researchers from Oregon State University discovered that two cannabinoid acid pairs bind to the spike protein of SARS-CoV-2, preventing the virus from completing a crucial step in infecting people.
Richard van Breemen is a researcher at Oregon State’s Global Hemp Innovation Center. He was also the study lead. He stated in a statement ‘These cannabinoid acids are abundant in hemp, and in many hemp extracts.
They aren’t controlled substances like THC, which is the psychoactive ingredient in cannabis, and they have a high safety profile in humans.
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“Our research revealed that hemp compounds are equally effective against variants SARS-CoV-2. This includes variant B.1.1.7 which was first discovered in the United Kingdom and variant B.1.351 which was first found in South Africa.
These compounds are CBGA and CBDA. The spike protein is also used in COVID-19 vaccinations and antibody therapy.
The researchers found that the cannabis compounds can be taken orally, and are abundant in hemp, and prevented the beta and alpha variants of the virus from infecting human cells. However, the team points out that those are only the two variants they have studied.
SARS-CoV-2 is distinguished by protrusions shaped like crowns on its outer surface. It also contains RNA strands that code its main structural proteins (spike, envelope, membrane, and nuclecapsid), as well as 16 other nonstructural proteins and a few ‘accessory proteins’, van Breemen stated.
He stated that any part of the replication and infection cycle could be a target for antiviral intervention. The connection of the spike protein’s receptor binding domain and the human cell surface receptor ACE2 was a crucial step in that cycle.
“This means that cell entry inhibitors such as the acids from hemp could be used to prevent SARS/CoV-2 infection, and also to reduce infections by preventing virus particles from infecting human cells.
They bind to the spike proteins so that those proteins cannot bind the ACE2 enzyme. This enzyme is found abundantly on the outer membranes of endothelial cells in the lungs and other parts of the body.
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SARS-CoV-2 is distinguished by protrusions resembling crowns on its outer surface. It also contains RNA strands that encode the four main structural proteins (spike, envelope, membrane, and nuclecapsid) as well as 16 other nonstructural proteins and several ‘accessory proteins.
It is not a new idea to use compounds to inhibit virus-receptor interaction. This has been used in the treatment of HIV-1 and hepatitis.
Van Breeman stated ‘One of the main concerns in the pandemic was the spread of variants. Of which, there are many. B.1.1.7, B.1.351 and B.1.351 are the most widespread and concerning.
These variants are well-known for being able to evade antibodies against early lineage SARS/CoV-2. This is clearly concerning considering that current vaccine strategies rely on early lineage spike protein (an antigen)
“Our data shows that CBDA and CBGA have been effective against the two variants of CBGA we examined, and we expect that this trend will continue to other variants.”